Systems thinking and complexity science methods and the policy process in non-communicable disease prevention: a systematic scoping review protocol

Introduction Given the complex causal origins of many non-communicable diseases (NCDs), and the complex landscapes in which policies designed to tackle them are made and unfold, the need for systems thinking and complexity science (STCS) in developing effective policy solutions has been emphasised.While numerous methods informed by STCS have been a

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Recent Use of Novel Data Streams During Foodborne Illness Cluster Investigations by the United States Food and Drug Administration: Qualitative Review

AbstractFoodborne illness is a continuous public health risk.The recognition of signals indicating a cluster of foodborne illness is key to the detection, mitigation, and prevention of foodborne adverse event incidents and outbreaks.With increased internet availability and access, novel data streams (NDSs) for foodborne illness reports initiated by

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Combination of farnesyl-transferase inhibition with KRAS G12D targeting breaks down therapeutic resistance in pancreatic cancer

Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has been a milestone in the history of KRAS mutant tumors; however, therapeutic resistance limits

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Infantile Periocular Capillary Hemangioma An Unusual Presentation

A 22 days old infant presented with a large capillary hemangioma involving the right lower eyelid causing a total occlusion of the visual visceratuant axis.The treatment given was a single intralesional triamcinolone acetonide injection (0.4 mg), followed a month later with systemic steroids (4mg) for 6 weeks.After wiha 77891 6 weeks, there was a s

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